"When Enola Holmes, sister to the detective Sherlock Holmes, discovers her mother has disappeared, she quickly embarks on a journey to London in search of her. But nothing can prepare her for what awaits. Because when she arrives, she finds herself involved in the kidnapping of a young marquess, fleeing murderous villains, and trying to elude her shrewd older brothers--all while attempting to piece together clues to her mother's strange disappearance....

While fourteen-year-old Enola Holmes endeavors to save her friend Lady Cecily Alistair from an unwelcome arranged marriage, she meets with some assistance from her older brother, Sherlock, and interference by the eldest, Mycroft.

After fourteen-year-old Enola Holmes seeks the missing Duquessa Del Campo in the seedy underbelly of nineteenth-century London, she finally reaches an understanding with her brothers Sherlock and Mycroft.