Despite his overwhelming fear of interacting with people, Christopher, a mathematically-gifted, autistic, fifteen-year-old boy, decides to investigate the murder of a neighbor's dog and uncovers secret information about his mother.

For fourteen-year-old Wallis Ann Stamper and her family, life in the Appalachian Mountains is simple and satisfying, though not for the tenderhearted. While her older sister, Laci--a mute, musically gifted savant--is constantly watched over and protected, Wallis Ann is as practical and sturdy as her name. When the Tuckasegee River bursts its banks, forcing them to flee in the middle of the night, those qualities save her life. But though her family...

"Penny has never met anyone smarter than her. That's par for the course when you're a savant--one of less than one hundred in the world. But despite her photographic memory and super-powered intellect, there's one question Penny doesn't know the answer to: where did her father go when he left her and her mother years ago? On Penny's 21st birthday, she receives a card in the mail from her father, just as she has every year since he left. But this birthday...

Shaun's proposed treatment for a homeless patient puts him and Jared in Andrews' crosshairs. Meanwhile, Claire tries to overcome Melendez' reluctance to do a risky heart operation while Glassman must overcome his personal feelings about his oncologist, Dr. Marina Blaize, and face a difficult decision about his health.

The show is about a young surgeon with autism who is recruited to work at a pediatric unit of a hospital. The hospital is known for treating many of the toughest cases a surgeon could ever see, but with autism comes clarity that most surgeons will never have. The television series focuses on the relationship between the doctor and patient, and how a man who cannot relate to the people who he tries to help.

A self-involved young man is shocked to discover that his millionaire father left most of his estate to an unknown beneficiary. The man tracks down said beneficiary, who turns out to be his brother and an autistic savant.

Christian Wolff is a math savant who works as a freelance accountant for some of the world's most dangerous criminal organizations. With the Treasury Department's Crime Enforcement Division starting to close in, he takes on a legitimate client, a robotics company where an accounting clerk has discovered a discrepency involving millions of dollars. But as Christian uncooks the books and gets closer to the truth, the body count starts to rise.