Determined to be brave, six-year-old Ramona Quimby has to deal with starting first grade, her mother's new job, and a teacher who does not understand how hard it is for Ramona to grow up.

Ramona's year in third grade is highlighted by the arrival of Howie's rich Uncle Hobart, a change in her after-school situation, a surprise wedding, a death and a new arrival in the family, and her father's getting a job.