When a young boy vanishes, a small town uncovers a mystery involving secret experiments, terrifying supernatural forces and one strange little girl. It's 1984 and the citizens of Hawkins, Indiana are still reeling from the horrors of the demagorgon and the secrets of Hawkins Lab. Will Byers has been rescued from the Upside Down but a bigger, sinister entity still threatens those who survived.

Carrie White, a sheltered high school girl and outcast, unleashes her newly developed telekinetic powers after she is pushed too far by her peers at the senior prom when they decide to pull a prank on her.

Nick is a 'mover' - someone who can move things with his mind. He meets up with Cassie who is a 'watcher' - someone who can predict the future. She is trying to rescue her mother from the government. As they try to piece things together, Kira enters their lives. Kira is a 'pusher' - someone who can influence the thoughts of others. She has had a relationship with Nick and is the only person to survive a powerful 'enhancement' drug that was administered...

John's life has become a nightmare. He is being hunted by the police for a series of murders he knows nothing about. A woman claiming to be his wife is after him, as is a mysterious 'doctor.' But his worst trouble comes in the form of The Strangers. They are vastly powerful beings who seem to manipulate just about everything in the city. They want John because of the extraordinary powers he manifests. John decides to find out what is happening in...