Stoner icons Jay and Silent Bob embark on a cross-country mission to stop a Hollywood reboot of an old movie based on them.

When horror star Paul Toombes's fiance is brutally killed, he loses more than this job, he also loses his mind. But twelve years after suffering a nervous breakdown, the washed-up horror legend agrees to do a TV series based on his old screen creation, the monstrous 'Dr. Death'. Soon the cast and crew of the series begin dying in ways similar to the deaths the characters suffered in the actor's old movies.

Movie star Vincent Chase, together with his boys, Eric, Turtle, and Johnny, is back, and back in business with super agent turned studio head Ari Gold. Some of their ambitions have changed, but the bond between them remains strong as they navigate the capricious and often cutthroat world of Hollywood.