Pursued by her much older brother, famed detective Sherlock Holmes, fourteen-year-old Enola, disguised and using false names, attempts to solve the kidnapping of a baronet's sixteen-year-old daughter in nineteenth-century London.

After fourteen-year-old Enola Holmes seeks the missing Duquessa Del Campo in the seedy underbelly of nineteenth-century London, she finally reaches an understanding with her brothers Sherlock and Mycroft.