In the 1930s, New York is swarming with Europe's ousted dreamers, alien families adapting to a new world. Rose Meadows unknowingly enters the lives of one such family when she answers an ad for an "assistant" to a Herr Mitwisser, the patriarch of a large household living in an obscure little neighborhood, in a remote corner of the sparse and weedy northeast Bronx. With an uncertain future, and no clear idea of her duties, Rose-orphaned at eighteen...

With only a yellowing photograph in hand, a young man - also named Jonathan Safran Foer - sets out to find the woman who might or might not have saved his grandfather from the Nazis. Accompanied by an old man haunted by memories of the war, an amorous dog named Sammy Davis, Junior, Junior, and the unforgettable Alex, a young Ukrainian translator who speaks in a sublimely butchered English, Jonathan is led on a quixotic journey over a devastated landscape...