Forensic psychiatrist Lily Dominick finds her career and her sanity threatened when she encounters a client who claims to be two hundred years old and the inspiration behind three of the nineteenth century's gothic literary classics.

In the wake of an ongoing string of high-profile murder-suicides in San Francisco, forensic psychiatrist Jo Beckett is hired by the SFPD to perform investigative autopsies and discovers a harrowing commonality among the suicide victims.

The enigmatic Dr. Helen Magnus and her team are on a mission to protect and study strange creatures that are secretly living among us. Along with their newest recruit, forensic psychiatrist Will Zimmerman, the group must face their darkest fears and their worst nightmares in order to provide a safe haven for the monsters that lurk in the shadows.