Picking up immediately after the events in Resident Evil: Retribution, Alice is the only survivor of what was meant to be humanity's final stand against the undead. Now, she must return to where the nightmare began, The Hive in Raccoon City, where the Umbrella Corporation is gathering its forces for a final strike against the only remaining survivors of the apocalypse.

Thanks to biological warfare, human life on Earth has just about been decimated. Los Angeles is a windswept ghost town where Robert Neville drives his convertible through sunlit streets foraging for supplies. He makes certain that he gets undercover before sundown, when other "inhabitants" emerge. Robert has to fend off attacks by The Family, sinister neopeople spawned by the plague. He becomes a man with a mission after meeting Lisa, another uninfected...

U.S. agent Leon Kennedy goes to Eastern Europe to see if the rumors about Bio Organic Weapons (BOWs) in their war are true. He decides to stay and fight to end the BOWs. The latest of the Resident Evil series, based on the Japanese video game and computer animated.

Picking up immediately after the events in Resident Evil: Retribution, Alice is the only survivor of what was meant to be humanity's final stand against the undead. Now, she must return to where the nightmare began, The Hive in Raccoon City, where the Umbrella Corporation is gathering its forces for a final strike against the only remaining survivors of the apocalypse.